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Trillium® Biosurface's structure mimics critical characteristics of the vascular endothelium.
Trillium®* Biosurface is a polymer coating with heparin applied to the blood-contacting surfaces of cardiopulmonary bypass devices. Its structure mimics critical characteristics of the vascular endothelium by providing a hydrophilic, negatively charged surface that features heparin.
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Trillium© Biosurface clinical and scientific findings published in peer-reviewed cardiovascular surgery, perfusion and scientific literature include:
Note: Citations with bold font represent clinical studies. Citations with standard font represent in vivo and in vitro studies.
*Technology licensed under agreement from BioInteractions, Limited, United Kingdom.
Blood is naturally compatible with vascular endothelium, not artificial surfaces.
Blood recognises the extracorporeal circuit surfaces as “foreign,” triggering coagulation and inflammatory events that may lead to adverse patient outcomes.
Responses to Blood-Material Contact
Biocompatible surfaces for Medtronic extracorporeal circulation technologies mimic critical characteristics of the vascular endothelium.
Warnings: A strict anticoagulation protocol should be followed and anticoagulation should be routinely monitored during all procedures. The benefits of extracorporeal support must be weighed against the risk of systematic anticoagulation and must be assessed by the prescribing physician.
Caution: For a complete listing of indications, contraindications, precautions and warnings, please refer to the Instructions for Use which accompany each product.
Dickinson T, et al. Trillium®-coated oxygenators in adult open-heart surgery: a prospective randomized trial. JECT 2002;34;248-253.
Baksaas ST, et al. In vitro evaluation of new surface coatings for extracorporeal circulation. Perfusion 1999;14:11-19.
Tevaeari HT, et al. Trillium coating of cardiopulmonary bypass circuits improves biocompatibility. Int J Artif Organs 1999;22:629-634.
Palanzo DA, et al. Effect of Trillium® Biopassive Surface coating of the oxygenator on platelet count during cardiopulmonary bypass. Perfusion 1999;14:473-479.
Cazzaniga A, et al. Trillium® biopassive surface: a new biocompatible treatment for extracorporeal circulation circuits. Int J Organs 2000;23:319-24.
Mueller XM, et al. Antithrombotic properties of trillium coated connectors. ASAIO J 2002;48:483-6.
van den Goor J, et al. Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response. Eur J Cardiothorac Surg 2004;26:926-931.
Lamba NMK, Cooper SL. Interaction of blood with artificial surfaces. In: Coleman RW, Clowes AW, George JN, Hirsh J, Marder V, eds. Hemostasis and thrombosis: Basic principles and practice, 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2001:661-672.
Edmunds LH, Stenach N. Blood-surface interface. In: Gravlee GP, Davis RF , Jurusz M, Utley JR, eds. Cardiopulmonary bypass: Principles and practice, 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2000:149-166.
Coleman RW, Clowes AW, George JN, Hirsh J, Marder V. Overview of Hemostasis. In: Coleman RW, Clowes AW, George JN, Hirsh J, Marder V, eds. Hemostasis and thrombosis: Basic principles and practice, 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2001:3-16.
Baier RE , Dutton RC . Initial events in interactions of blood with a foreign surface. J Biomed Mater Res. 1969;3(1):191-206.
Paparella D, Yau TM , Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg. 2002 ;21(2):232-244.