Avalus™ Bioprosthesis for Heart Valve Replacement
The Avalus bioprosthesis is a pericardial aortic surgical valve designed for better overall performance, improved implant experience, and a contemporary design to facilitate future valve-in-valve (ViV).
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Overview
Designed for Life. See Avalus in action.
Our Avalus valve is the next-generation stented pericardial aortic valve — a powerful synergy of over 40 years of industry experience and proven valve design — for excellent implantability for you and performance for your patients.
Avalus™ Experience
Product Details
Leading in evidence.
Excelling in performance.
Stable gradients at 7 years,
Large, Industry leading EOAs
and low rates of PPM1
with the Avalus™ valve
The Avalus valve has
Excellent Durability
with 99% freedom from reintervention for
SVD/SHD2
At 7 years
Excellent long-term clinical outcomes
with 95% of patients in NYHA I or II and 99% freedom
from valve-related mortality2
A Design Platform for Long-term Durability*
Interior-mounted leaflets minimize damaging contact with the frame — a design platform for long-term durability.
- Supra-annular design to enhance hemodynamics3,4
- Three laser-cut bovine pericardial leaflets matched for thickness and deflection to provide consistent performance
- Two-part polymer frame minimizes stress zones on leaflets
- Sewing markers facilitate suture placement and valve orientation
AOA™ tissue treatment* to mitigate calcification — over 20 years of clinical use in the Medtronic surgical tissue valve portfolio.1,2
Ease of Implant for You
Polyetheretherketone (PEEK) polymer stent provides strength and flexibility and offers resistance to permanent deformation.
- Soft and pliable sewing cuff facilitates needle penetration, suture placement, and valve seating for an improved implant experience
- Lower valve profile and narrow commissure posts expand ostia clearance and give you more space for knot tying
- Streamlined valve holder improves visibility in both standard and minimally invasive approaches
- Simple one-cut release
Performance and Lifetime Management for Your Patients
- Valve dimensions and geometry enable future ViV replacements
- PEEK base frame impregnated with barium sulfate provides for radiopacity and visibility
- Polymer frame mitigates the risk of potential metal-on-metal corrosion with transcatheter stent materials
- MRI safe in all MR environments without conditions
Designed to achieve 100% coaptation and minimize central regurgitation.
Flexible support frame with firm base designed to maintain circularity and consistent hemodynamic performance.
Product Specifications and Ordering Information
Avalus Valve Ordering and Specifications
| Avalus Valve Order Number |
Valve Size (mm) |
Stent Diameter (TAD†) (mm) |
Internal Orifice Diameter‡ (mm) |
External Sewing Ring Diameter (mm) |
Valve Profile Height (mm) |
Aortic Protrusion (mm) |
|
|---|---|---|---|---|---|---|---|
|
|
|
(1) |
(2) |
(2a) |
(3) |
(4) |
(5) |
| 40019 |
19 |
19 |
17.5 |
18 |
27.0 |
13.0 |
11.0 |
| 40021 |
21 |
21 |
19.5 |
20 |
29.0 |
14.0 |
12.0 |
| 40023 |
23 |
23 |
21.5 |
22 |
31.0 |
15.0 |
13.0 |
| 40025 |
25 |
25 |
23.5 |
24 |
33.0 |
16.0 |
14.0 |
| 40027 |
27 |
27 |
25.5 |
26 |
36.0 |
17.0 |
15.0 |
| 40029 |
29 |
29 |
27.5 |
28 |
37.0 |
18.0 |
16.0 |
Avalus Valve Accessories
| Order Number |
Description |
|---|---|
| 7420 |
Valve Handle |
| 7400S |
Avalus Sizers |
| T7400 |
Tray, Accessory, Avalus |
Additional Resources
Medical Education
Training, education, and collaboration on the treatment of mitral and tricuspid valve disease.
Learn More
*
No clinical data is available which evaluates the long-term impact of AOA treatment in patients.
†
TAD — tissue annulus diameter.
‡
Measurement shows stent frame including tissue (2) and stent frame excluding tissue (2a).
References
1
Klautz RJM, Rao V, Reardon MJ, et al. Hemodynamic function of contemporary surgical aortic valves 1-year postimplant. Abstract presented at: 37th Annual Meeting of the European Association for Cardio-Thoracic Surgery, Vienna, Austria. October 4–7, 2023.
2
Sabik JF III, Rao V, Moront MG, et al. 7-Year follow-up of >1100 patients who received a contemporary pericardial aortic bioprosthesis. Presented at: 38th Annual Meeting of the European Association for Cardio-Thoracic Surgery; October 9-12, 2024; Lisbon, Portugal.
3
Medtronic Freestyle™ aortic root bioprosthesis was first implanted clinically in August 1992. Freestyle Aortic Root Bioprosthesis 15-Year Clinical Compendium. © 2016 Medtronic.
4
Ruzicka DJ, Hettich I, Hutter A, et al. The complete supraannular concept: in vivo hemodynamics of bovine and porcine aortic bioprostheses. Circulation. September 15, 2009;120(11 Suppl):S139-145.