VenaSeal™ Closure System Superficial Vein Therapies

The VenaSeal closure system delivers immediate and lasting vein closure with its proprietary medical adhesive formula, with a demonstrated 94.6% closure rate at 5 years.1-5

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Discover the VenaSeal System  Difference

Simple innovations to the VenaSeal closure system plus new techniques mean greater impact for you and your practice.

Designed for  Patient Comfort

Simpler procedure, faster recovery1-4,6,7

  • Nonthermal
    • No risk of thermal nerve injury
    • Less pain and bruising than thermal treatment1,2
  • Nontumescent
    • Limited needle sticks
  • Rapid recovery with same-day return to daily activities
  • No post-procedure compression stockings‡2,4

Man and a woman dancing in a kitchen

Product Details

Immediate Vein Closure

Deliver immediate and lasting vein closure with our proprietary medical adhesive.1-5

Glass vial with 5 cc of VenaSeal closure system adhesive
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View a live VenaSeal procedure performed by Dr. Kathleen Gibson.

VenaSeal Procedure Animation

View a VenaSeal Closure System procedure animation to see how it works.

The VenaSeal closure system procedure offers:

  • Rapid return to normal activities after treatment1,3
  • Minimized pain, tenderness, and ecchymosis3
  • Significant improvements in quality of life6

The VenaSeal closure system procedure eliminates2,4:

  • Tumescent anesthesia
  • Thermal nerve injury
  • Post-procedure compression stockings

Features and Benefits 

Illustration of adhesive being placed in the vein via a small catheter


The proprietary catheter is highly visible under ultrasound, allowing precise delivery of the adhesive. The dispensing gun precisely controls the amount of adhesive, delivering 0.10 cc aliquots with each trigger pull.

Polymerization of the VenaSeal adhesive at 0, 24, and 54 seconds


Upon contact with blood, the adhesive begins to bond with the intima and compression is applied to close the vein. The adhesive was designed to remain permanently in the diseased vein and is encapsulated by chronic fibrosis.7

Gloved hand holding VenaSeal adhesive bottle with syringe


The viscosity of the adhesive is specifically designed to minimize migration and embolization.

Man in blue shirt stretching legs


The adhesive is designed to be soft and flexible, and less likely to be felt by the patient.

VenaSeal Patient Testimonials 

Steve's Story

Hear about Steve's experience with the VenaSeal closure system.

Heather's Story

Hear about Heather's experience with the VenaSeal closure system.

Clinical Evidence

VenaSeal Clinical Evidence

Building long-term evidence with high clinical standards

See More Clinical Evidence


The VenaSeal Closure System is intended for the permanent, complete, endovascular adhesive closure of the great saphenous vein (GSV) and associated varicosities in the treatment of venous reflux disease.

Technical Resources

Instructions for Use

Find the technical guide in the product labeling supplied with each device.

System Components 

  1. Adhesive
  2. Plunger
  3. Release Button
  4. Trigger
  5. Dispensing Tip
  6. Catheter
VenaSeal closure system with callouts detailing separate components

Model Specifications


VenaSeal Adhesive

Five (5) cc of the VenaSeal adhesive (a specially formulated n-butyl-2-cyanoacrylate) is contained within a screwed-capped vial.

Dispenser Gun

The dispenser gun consists of a pistol type, ergonomic handle with an integrated barrel and trigger. Each depression of the trigger delivers a controlled, 0.10 cc (range: 0.06–0.12 cc) amount of adhesive.


The catheter is 5 Fr with an effective length of 91 cm, laser markings at 3 cm and 85 cm from the tip, and high echogenic visibility.


The introducer is 7 Fr with an effective length of 80 cm, with 10 mm spaced, circumferential markings along its length for measuring retraction length during the VenaSeal procedure.


The dilator is 5 Fr with an effective length of 87 cm.


The 3 cc syringes are graduated Monoject™ Luer Lock syringes, each with a standard threaded Luer Lock connector.

Dispenser Tips

The dispenser tips are each comprised of a stainless steel, 1.5 mm ID, 3.8 cm length hypotube with a Luer Lock connector.


The guidewire is a 0.035 in, 180 cm J-wire guidewire.

Additional Resources

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ClosureFast Radiofrequency Ablation System

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™Third party brands are trademarks of their respective owners.

All statements of being “greater” are as compared to previous version and procedure technique.

Some patients may benefit from the use of compression stockings post-procedure.



Morrison N, Gibson K, McEnroe S, et al. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. April 2015;61(4):985-994.


Proebstle T, Alm J, Dimitri S, et al. Three-year follow-up results of the prospective European Multicenter Cohort Study on Cyanoacrylate Embolization for treatment of refluxing great saphenous veins. J Vasc Surg Venous Lymphat Disord. March 2021;9(2):329-334.


Gibson K, Ferris B. Cyanoacrylate closure of incompetent great, small and accessory saphenous veins without the use of post-procedure compression: Initial outcomes of a post-market evaluation of the VenaSeal System (the WAVES Study). Vascular. April 2017;25(2):149-156.


Almeida JI, Javier JJ, Mackay EG, Bautista C, Cher DJ, Proebstle TM. Thirty-sixth month follow-up of first-in-human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. September 2017;5(5):658-666.


Morrison N, Gibson K, Vasquez M, Weiss R, Jones A. Five-year extension study of patients from a randomized clinical trial (VeClose) comparing cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. J Vasc Surg Venous Lymphat Disord. November 2020;8(6):978-989.


Morrison N, Gibson, Vasquez M, et al. VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg. 2017;5(3):321-330.


Morrison, N. VenaSeal Closure System vs. Radiofrequency Ablation for Incompetent Great Saphenous Veins (VeClose). 36-Month Results presented at: IVC; April 20, 2017; Miami, FL.