Education and training

Renal denervation for hypertension

Find courses, webinars, and other educational activities for
hypertension and the Symplicity™ blood pressure procedure
(also called renal denervation).

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Webinars and peer-to-peer videos


Long-term safety and efficacy of RDN 

Professor Felix Mahfoud presents the SPYRAL HTN-ON MED pilot study data at ACC 2022 detailing the long-term safety and efficacy of renal denervation with the Symplicity blood pressure procedure.

A video featuring Profs. Felix Mahfoud, Roland Schmieder, and Flavio Ribichini discussing key findings on renal denervation (RDN).

MACE risk reductions

Professors Felix Mahfoud, M.D., Roland Schmieder, M.D., and Flavio Ribichini, M.D.,discuss key fndings on RDN.

Real-world outcomes

Professor Felix Mahfoud discusses real-
world outcomes of the Symplicity procedure from the GLOBAL SYMPLICITY REGISTRY.

The science of the procedure

Professor Andrew Sharp explores the science of the Symplicity blood pressure procedure from a proceduralist’s perspective.

Build your RDN knowledge

Browse online courses and many other educational resources about the Symplicity blood pressure procedure, clinical evidence, and practical clinical application.

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Education programs

Discover our Renal Denervation Education Programs that run throughout the year including online workshops, simulator workshops and in-person meetings.

Physician education sites

Learn about the latest on renal denervation from third party education sites, including those offering CME credits.

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Select the right patients

See which types of patients could beneft from the Symplicity blood pressure procedure.

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Extensive clinical evidence

The Symplicity blood pressure procedure is supported by multiple clinical trials and a real-world patient registry.1-4

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Transforming hypertension treatment

The Symplicity blood pressure procedure is changing how patients with hypertension can reduce their blood pressure.


Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. The Lancet. 2022;399:1401-1410.


Mahfoud F, Mancia G, Schmieder R, et al. Three-year safety and efficacy in the Global Symplicity Registry: Impact of antihypertensive medication burden on blood pressure reduction. Presented at PCR e-course 2020.


Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. The Lancet. 2020;395:1444-1451.


Kandzari DE, Böhm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. The Lancet. 2018;391(10137):2346.


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