Renal denervation products

Healthcare professionals

Alert Indications, Safety, and Warnings

Symplicity Spyral™ renal denervation system

For treating hypertension

The Symplicity Spyral™ renal denervation system complements medication and lifestyle changes with an effective, evidence-based procedural approach to hypertension treatment.¹⁻⁴

Indications, Safety, and Warnings
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A hand in a white surgical glove holds the Symplicity Spyral multi-electrode renal denervation catheter
A report icon represents multiple randomized controlled trials for this procedure.

Extensive clinical evidence

The Symplicity Spyral system is proven to achieve safe and clinically meaningful blood pressure reduction in multiple clinical trials and a real-world patient registry.1-4

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Take action on hypertension

Gain access to training, education, and tools to successfully introduce the Symplicity Spyral system to your referring community and patients.

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1

Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. The Lancet. 2020;395:1444–1451.

2

Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. The Lancet. Published online April 4, 2022.

3

Mahfoud F, Mancia G, Schmieder R, et al. Three-year safety and efficacy in the Global Symplicity Registry: Impact of antihypertensive medication burden on blood pressure reduction. Presented at PCR e-course 2020.

4

Kandzari DE, Böhm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. The Lancet. 2018;391(10137):2346–2355.

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